Determining reference ranges and sample sizes in parallel-group studies.

ABSTRACT:

Background and objectives

Reference ranges are widely used to locate the major range of the target probability distribution. When future measurements fall outside the reference range, they are classified as atypical and require further investigation. The fundamental principles and statistical properties of reference ranges are closely related to those of tolerance interval procedures. Existing investigations of reference ranges and tolerance intervals mainly devoted to the primitive cases of one- and paired-sample designs. Although reference ranges hold considerable promise for parallel group designs, the corresponding methodological and computational issues for determining reference limits and sample sizes have not been adequately addressed.

Methods

This paper describes a c

SUBMITTER: Shieh G 

PROVIDER: S-EPMC9710766 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature