Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs.

ABSTRACT: Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, the lack of a self-regulated glucagon release module limits their clinical applications due to the potential risk of hypoglycemia. Here, we describe a transdermal polymeric microneedle patch for glucose-responsive closed-loop insulin and glucagon delivery to achieve glycemic regulation with minimized risk of hypoglycemia. The glucose-responsive phenylboronic acid units can bind to glucose to reversibly shift the net charge (from positive to negative) of the entire polymeric matrix within microneedles. Therefore, the release ratio of the negatively charged insulin and the positively charg

SUBMITTER: Yang C 

PROVIDER: S-EPMC9710866 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature