Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study.

ABSTRACT:

Background

The combined impact of immunity and SARS-CoV-2 variants on viral kinetics during infections has been unclear.

Methods

We characterized 1,280 infections from the National Basketball Association occupational health cohort identified between June 2020 and January 2022 using serial RT-qPCR testing. Logistic regression and semi-mechanistic viral RNA kinetics models were used to quantify the effect of age, variant, symptom status, infection history, vaccination status and antibody titer to the founder SARS-CoV-2 strain on the duration of potential infectiousness and overall viral kinetics. The frequency of viral rebounds was quantified under multiple cycle threshold (Ct) value-based definitions.

Results

Among individuals detected partway through their infection,

SUBMITTER: Hay JA 

PROVIDER: S-EPMC9711520 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature