Allostatic Load and Adverse Pregnancy Outcomes.

ABSTRACT:

Objective

To assess the association between allostatic load, as an estimate of chronic stress, and adverse pregnancy outcomes.

Methods

This was a secondary analysis of nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be), a prospective observational cohort study. Our primary exposure was dichotomous high allostatic load in the first trimester, defined as 4 or more of 12 biomarkers in the "worst" quartile. The primary outcome was a composite adverse pregnancy outcome: hypertensive disorders of pregnancy (HDP), preterm birth, small for gestational age (SGA), and stillbirth. Secondary outcomes included components of the composite. Multivariable logistic regression was used to test the association between high allostatic load and adverse pregnancy outcomes, a

SUBMITTER: Lueth AJ 

PROVIDER: S-EPMC9712159 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature