Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial.

ABSTRACT: Previous proton magnetic resonance spectroscopy (¹H-MRS) studies suggest a perturbation in glutamate and/or GABA in Major Depressive Disorder (MDD). However, no studies examine the ratio of glutamate and glutamine (Glx) to GABA (Glx/GABA) as it relates to depressive symptoms, which may be more sensitive than either single metabolite. Using a within-subject design, we hypothesized that reduction in depressive symptoms correlates with reduction in Glx/GABA in the anterior cingulate cortex (ACC). The present trial is a randomized clinical trial that utilized ¹H-MRS to examine Glx/GABA before and after 8 weeks of escitalopram or placebo. Participants completed the 17-item Hamilton Depression Rating Scale (HDRS₁₇) and underwent magnetic resonance spectroscopy be

SUBMITTER: Narayan GA 

PROVIDER: S-EPMC9712215 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature