Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development.

ABSTRACT:

Background

The path to childhood asthma is thought to initiate in utero and be further promoted by postnatal exposures. However, the underlying mechanisms remain underexplored. We hypothesized that prenatal maternal immune dysfunction associated with increased childhood asthma risk (revealed by low IFN-γ:IL-13 secretion during the third trimester of pregnancy) alters neonatal immune training through epigenetic mechanisms and promotes early-life airway colonization by asthmagenic microbiota.

Methods

We examined epigenetic, immunologic, and microbial features potentially related to maternal prenatal immunity (IFN-γ:IL-13 ratio) and childhood asthma in a birth cohort of mother-child dyads sampled pre-, peri-, and postnatally (N = 155). Epigenome-wide DNA methylation and cytokin

SUBMITTER: DeVries A 

PROVIDER: S-EPMC9712226 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature