Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.

ABSTRACT:

Purpose

To assess the reliability of measuring diffusivity, diffusional kurtosis, and cellular-interstitial water exchange time with long diffusion times (100-800 ms) using stimulated-echo DWI.

Methods

Time-dependent diffusion MRI was tested on two well-established diffusion phantoms and in 5 patients with head and neck cancer. Measurements were conducted using an in-house diffusion-weighted STEAM-EPI pulse sequence with multiple diffusion times at a fixed TE on three scanners. We used the weighted linear least-squares fit method to estimate time-dependent diffusivity, D(t)$$ D(t) $$ , and diffusional kurtosis, K(t)$$ K(t) $$ . Additionally, the Kärger model was used to estimate cellular-interstitial water exchange time ( τex$$ {\tau}_{ex} $$ ) from K(t)$$ K(t) $$ .

Resul

SUBMITTER: Solomon E 

PROVIDER: S-EPMC9712275 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature