Upper cerebellar glucose hypermetabolism in patients with temporal lobe epilepsy and interictal psychosis.

ABSTRACT:

Objective

Psychosis is an important comorbidity in epilepsy, but its pathophysiology is still unknown. The imaging modality ¹⁸ F-fluorodeoxyglucose-positron emission tomography (¹⁸ F-FDG PET) is widely used to measure brain glucose metabolism, and we speculated that ¹⁸ F-FDG PET may detect characteristic alteration patterns in individuals with temporal lobe epilepsy (TLE) and psychosis.

Methods

We enrolled 13 patients with TLE and interictal psychosis (TLE-P) and 21 patients with TLE without psychosis (TLE-N). All underwent interictal ¹⁸ F-FDG-PET scanning. Statistical Parametric Mapping (SPM)12 software was used for the normalization process, and we performed a voxel-wise comparison of the TLE-P and TLE-N groups.

Results

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SUBMITTER: Sone D 

PROVIDER: S-EPMC9712471 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature