Hepatitis A virus seroprevalence among children and adolescents in a high-burden HIV setting in urban South Africa.

ABSTRACT: Hepatitis A virus (HAV) infection is one of the most important global causes of viral hepatitis. Recent reviews suggested that HAV endemicity in South Africa could shift from high to intermediate. A hospital-based HAV seroprevalence study was conducted between February 2018 and December 2019 in Pretoria, South Africa. Systematic sampling was performed on children and adolescents (1-15 years) who attended outpatient services. Participants with a known HIV status and valid HAV serology results were included. Of the 1220 participants, the median age was 7 years (IQR: 4-11), with 648 (53.11%) males and 572 (46.89%) females. Of 628 (51.48%) HIV-infected participants, most (329, 71.83%) were both immunologically and virologically controlled or had low-level viremia (74, 16.16%). Almost three-qua

SUBMITTER: du Plessis NM 

PROVIDER: S-EPMC9712520 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature