Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels.

ABSTRACT: There is increasing appreciation that, in addition to being shaped by an individual's genotype and environment, most complex traits are also determined by poorly understood interactions between these two factors. So-called "genotype × environment" (G×E) interactions remain difficult to map at the organismal level but can be uncovered using molecular phenotypes. To do so at large scale, we used TM3'seq to profile transcriptomes across 12 cellular environments in 544 immortalized B cell lines from the 1000 Genomes Project. We mapped the genetic basis of gene expression levels across environments and revealed a context-dependent genetic architecture: The average heritability of gene expression levels increased in treatment relative to control conditions, and on average, each treatment reveale

SUBMITTER: Lea AJ 

PROVIDER: S-EPMC9712631 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature