Oral Lichen Planus and Oral Squamous Cell Carcinoma share key oncogenic signatures.

ABSTRACT: To investigate similarities in the gene profile of Oral Lichen Planus and Oral Squamous Cell Carcinoma that may justify a carcinogenic potential, we analyzed the gene expression signatures of Oral Lichen Planus and Oral Squamous Cell Carcinoma in early and advanced stages. Based on gene expression data from public databases, we used a bioinformatics approach to compare expression profiles, estimate immune infiltrate composition, identify differentially and co-expressed genes, and propose putative therapeutic targets and associated drugs. Our results revealed gene expression patterns related to processes of keratinization, keratinocyte differentiation, cell proliferation and immune response in common between Oral Lichen Planus and early and advanced Oral Squamous Cell Carcinoma, with the co

SUBMITTER: de Lanna CA 

PROVIDER: S-EPMC9712651 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature