Dataset Information

Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus.

ABSTRACT: Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogenesis (WIHN) were reduced because of suppression of Wnt/β-catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that activates Wnt/β-catenin signaling, restored the capabilities of regrowth and WIHN in diabetic mice. The Wnt/β-catenin signaling activator also increased the length of the human hair follicle which was decreased under high glucose culture conditions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/β-catenin signaling pathway. Consequently, the usage of Wnt/β-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients. [BMB Reports 2022; 55(11): 559-564].

SUBMITTER: Ryu YC

PROVIDER: S-EPMC9712708 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus.

Ryu Yeong Chan YC Kim You-Rin YR Park Jiyeon J Choi Sehee S Kim Geon-Uk GU Kim Eunhwan E Hwang Yumi Y Kim Heejene H Bak Soon Sun SS Lee Jin Eun JE Sung Young Kwan YK Han Gyoonhee G Lee Soung-Hoon SH Choi Kang-Yell KY

BMB reports 20221101 11

Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozot ...[more]

PMID: 36016500

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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus.

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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus.

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