Human nasal olfactory stem cells, purified as advanced therapy medicinal products, improve neuronal differentiation.

ABSTRACT:

Background

Olfactory ecto-mesenchymal stem cells (OE-MSC) are mesenchymal stem cells derived from the lamina propria of the nasal mucosa. They display neurogenic and immunomodulatory properties and were shown to induce recovery in animal models of spinal cord trauma, hearing loss, Parkinsons's disease, amnesia, and peripheral nerve injury. As a step toward clinical practice, we sought to (i) devise a culture protocol that meets the requirements set by human health agencies and (ii) assess the efficacy of stem cells on neuron differentiation.

Methods

Nasal olfactory mucosa biopsies from three donors were used to design and validate the good manufacturing process for purifying stem cells. All processes and procedures were performed by expert staff from the cell therapy

SUBMITTER: Jaloux C 

PROVIDER: S-EPMC9713000 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature