Selinexor-based regimens in patients with multiple myeloma after prior anti-B-cell maturation antigen treatment.

ABSTRACT: There is a lack of consensus on therapy sequencing in previously treated multiple myeloma, particularly after anti-B-cell maturation antigen (BCMA) therapy. Earlier reports on selinexor (X) regimens demonstrated considerable efficacy in early treatment, and after anti-BCMA-targeted chimeric antigen receptor-T cell therapy. Here, we present data from 11 heavily pretreated patients who predominantly received BCMA-antibody-drug conjugate therapy. We observe that X-containing regimens are potent and achieve durable responses with numerically higher overall response and clinical benefit rates, as well as median progression free survival compared to patients' prior anti-BCMA therapies, despite being used later in the treatment course. In an area of evolving unmet need, these data reaffirm the ef

SUBMITTER: Baljevic M 

PROVIDER: S-EPMC9713049 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature