Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

ABSTRACT: Cell lines represent an essential tool used in preclinical research. Most hematologic malignancies have a wide array of cell lines representing their respective molecular and pathologic spectra. In mantle cell lymphoma (MCL), cell lines become specifically valuable in view of the heterogeneity of this disease. Unfortunately, the number of MCL cell lines that are available for the research community remains small, with only nine cell lines available for purchase through the American Type Culture Collection (ATCC). We have established a novel blastoid MCL cell line, isolated from the malignant pleural effusion of a 69-year-old male with refractory MCL. Arbo was fully characterized with cytogenetics, immunophenotyping, whole exome sequencing and drug sensitivity assays. One of the most notabl

SUBMITTER: Safa F 

PROVIDER: S-EPMC9713070 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature