Anxiety symptoms and puberty interactively predict lower cingulum microstructure in preadolescent Latina girls.

ABSTRACT: Preadolescence is a period of increased vulnerability for anxiety, especially among Latina girls. Reduced microstructure (fractional anisotropy; FA) of white matter tracts between limbic and prefrontal regions may underlie regulatory impairments in anxiety. However, developmental research on the association between anxiety and white matter microstructure is mixed, possibly due to interactive influences with puberty. In a sample of 39 Latina girls (8-13 years), we tested whether pubertal stage moderated the association between parent- and child-reported anxiety symptoms and FA in the cingulum and uncinate fasciculus. Parent- but not child-reported anxiety symptoms predicted lower cingulum FA, and this effect was moderated by pubertal stage, such that this association was only significant fo

SUBMITTER: Glenn DE 

PROVIDER: S-EPMC9713745 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature