Identifying single-strain growth patterns of human gut microbes in response to preterm human milk and formula.

ABSTRACT: The intestinal microbiota of the preterm neonate has become a major research focus, with evidence emerging that the microbiota influences both short and long-term health outcomes, in the neonatal intensive care unit and beyond. Similar to the term microbiome, the preterm gut microbiome is highly influenced by diet, specifically formula and human milk use. This study aims to analyze next-generation products including preterm formula, human milk-oligosaccharide term formula, and preterm breastmilk. We used a culture-based model to differentially compare the growth patterns of individual bacterial strains found in the human intestine. This model probed 24 strains of commensal bacteria and 8 pathobiont species which have previously been found to cause sepsis in preterm neonates. Remarkable dif

SUBMITTER: Engevik MA 

PROVIDER: S-EPMC9713831 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature