Integration of proteomic and metabolomic characterization in atrial fibrillation-induced heart failure.

ABSTRACT:

Background

The exact mechanism of atrial fibrillation (AF)-induced heart failure (HF) remains unclear. Proteomics and metabolomics were integrated to in this study, as to describe AF patients' dysregulated proteins and metabolites, comparing patients without HF to patients with HF.

Methods

Plasma samples of 20 AF patients without HF and another 20 with HF were analyzed by multi-omics platforms. Proteomics was performed with data independent acquisition-based liquid chromatography-tandem mass spectrometry (LC-MS/MS), as metabolomics was performed with LC-MS/MS platform. Proteomic and metabolomic results were analyzed separately and integrated using univariate statistical methods, multivariate statistical methods or machine learning model.

Results

We found 35 up-regulat

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9714089 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature