Clozapine haematological monitoring for neutropenia: a global perspective.

ABSTRACT:

Aims

Clozapine is licensed for treatment-resistant psychosis and remains underutilised. This may berelated to the stringent haematological monitoring requirements that are mandatory in most countries. We aimed to compare guidelines internationally and develop a novel Stringency Index. We hypothesised that the most stringent countries would have increased healthcare costs and reduced prescription rates.

Method

We conducted a literature review and survey of guidelines internationally. Guideline identification involved a literature review and consultation with clinical academics. We focused on the haematological monitoring parameters, frequency and thresholds for discontinuation and rechallenge after suspected clozapine-induced neutropenia. In addition, indicators reflecting mo

SUBMITTER: Oloyede E 

PROVIDER: S-EPMC9714212 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature