Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use.

ABSTRACT:

Background

Rodent paradigms and human genome-wide association studies (GWAS) on drug use have the potential to provide biological insight into the pathophysiology of addiction.

Methods

Using GeneWeaver, we created rodent alcohol and nicotine gene-sets derived from 19 gene expression studies on alcohol and nicotine outcomes. We partitioned the SNP heritability of these gene-sets using four large human GWAS: (1) alcoholic drinks per week, (2) problematic alcohol use, (3) cigarettes per day, and (4) smoking cessation. We benchmarked our findings with curated human alcohol and nicotine addiction gene-sets and performed specificity analyses using other rodent gene-sets (e.g., locomotor behavior) and other human GWAS (e.g., height).

Results

The rodent alcohol gene-set was e

SUBMITTER: Huggett SB 

PROVIDER: S-EPMC9714312 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature