Bayesian Estimation of Human Population Toxicokinetics of PFOA, PFOS, PFHxS, and PFNA from Studies of Contaminated Drinking Water.

ABSTRACT:

Background

Setting health-protective standards for poly- and perfluoroalkyl substances (PFAS) exposure requires estimates of their population toxicokinetics, but existing studies have reported widely varying PFAS half-lives (T_½) and volumes of distribution (V_d).

Objectives

We combined data from multiple studies to develop harmonized estimates of T_½ and V_d, along with their interindividual variability, for four PFAS commonly found in drinking water: perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS).

Methods

We identified published data on PFAS concentrations in human serum with corresponding drinking water measurements, separated into training

SUBMITTER: Chiu WA 

PROVIDER: S-EPMC9714558 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature