Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.

ABSTRACT:

Aim

Gastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes. The mechanism of action of metformin is associated with gut microbiota. However, the gut microbial community structure related to metformin-induced gastrointestinal adverse events remains unclear. This study aimed to investigate it.

Methods

50 patients with newly diagnosed diabetes were treated with metformin 1500mg/d for 12 weeks. The patients were divided into two groups according to whether gastrointestinal adverse events occurred (group B) or did not occur (group A) after treatment. The fecal bacterial communities and short-chain fatty acids (SCFAs) were sequenced and compared. 70 diabetes mice were randomly divided into 8 groups and treated with metformin (Met),

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9714661 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature