Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study.

ABSTRACT: Background and Objective: The public's safety has been significantly jeopardized by the pandemic of COVID-19, which is brought on by the highly virulent and contagious SARS-CoV-2 virus. Finding novel antiviral drugs is currently of utmost importance for the treatment of patients with COVID-19. Main protease (3CL^pro) of SARS-CoV-2 is involved in replication of virus, so it is considered as a promising target. Using small molecules to inhibit SARS-CoV-2-3CL^pro activity may be an effective way to prevent viral replication to fight COVID-19. Despite the fact that some SARS-CoV-2-3CL^pro inhibitors have been described, only few of them have high levels of inhibition at nanomolar concentrations. In this study, we aimed to screen out effective SARS-CoV-2-3CL

SUBMITTER: Wang H 

PROVIDER: S-EPMC9715617 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature