TSH-β gene polymorphism in Saudi patients with thyroid cancer: A case-control study.

ABSTRACT:

Background

The role of thyroid-stimulating hormone in the pathogenesis of thyroid cancer is not yet fully explored. This study aimed to evaluate the role of the TSH-β polymorphism in thyroid cancer in a Saudi cohort.

Methods

A prospective case-control study was conducted on 507 patients with differentiated thyroid carcinoma and compared them with 560 controls of Saudi origin. The association of two variants, the rs201857310, and rs7530810, in the TSH-β gene with thyroid cancer risk as well as thyroxine dose, were evaluated.

Results

The rs201857310_A > G [OR: 0.50 (95 % CI: 0.35-0.71); P < 0.0001] was strongly associated with thyroid cancer. The multivariable analysis adjusted the effect of possible confounders (age, sex, body mass index, and smoking). Multivari

SUBMITTER: AlRasheed MM 

PROVIDER: S-EPMC9715634 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature