Using developmental regression to reorganize the clinical importance of autistic atypicalities.

ABSTRACT: Early regression (ER) is often reported in autistic children with a prototypical phenotype and has been proposed as a possible pathognomonic sign present in most autistic children. Despite the uncertainties attached to its definition and report, using ER to anchor the autism phenotype could help identify the signs that best contribute to an autism diagnosis. We extracted retrospective data from 1547 autistic children between the ages of 6 and 18 years from the Simons Simplex collection. Logistic regression identified the atypicalities associated with a history of ER. Stepwise variable selection using logistic regression analysis followed by a bootstrap procedure of 1000 iterations identified the cluster of atypicalities best associated with ER. Linear and logistic regressions measured the

SUBMITTER: Gagnon D 

PROVIDER: S-EPMC9715666 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature