Transcriptomic analysis identifies shared biological foundations between ischemic stroke and Alzheimer's disease.

ABSTRACT:

Aim

Alzheimer's disease (AD) and ischemic stroke (IS), two major neurological diseases, are suggested to be associated in clinical and pathophysiological levels. Previous studies have provided some insights into the possible genetic mechanisms behind the correlation between AD and IS, but this issue is still not clear. We implemented transcriptomic analysis to detect common hub genes and pathways to help promote the understanding of this issue.

Materials and methods

Four gene expression profiling datasets (GSE16561, GSE58294, GSE63060, and GSE63061) of peripheral whole blood, which contain 108 IS samples, 284 AD samples, and 285 matched controls, were employed to detect differentially expressed genes (DEGs) for AD and IS, which were further analyzed for shared biological pat

SUBMITTER: Liu W 

PROVIDER: S-EPMC9715755 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature