Exercise haemodynamics in heart failure with preserved ejection fraction: a systematic review and meta-analysis.

ABSTRACT:

Aims

Exercise right heart catheterization (RHC) is considered the gold-standard test to diagnose heart failure with preserved ejection fraction (HFpEF). However, exercise RHC is an insufficiently standardized technique, and current haemodynamic thresholds to define HFpEF are not universally accepted. We sought to describe the exercise haemodynamics profile of HFpEF cohorts reported in literature, as compared with control subjects.

Methods and results

We performed a systematic literature review until December 2020. Studies reporting pulmonary artery wedge pressure (PAWP) at rest and peak exercise were extracted. Summary estimates of all haemodynamic variables were evaluated, stratified according to body position (supine/upright exercise). The PAWP/cardiac output (CO) slope du

SUBMITTER: Baratto C 

PROVIDER: S-EPMC9715813 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature