Within trial comparison of survival time projections from short-term follow-up with long-term follow-up findings.

ABSTRACT:

Aims

Data on long-term treatment effects are scarce, despite the intent to use new therapies for many years and the need of patients, physicians and payers to have a better understanding of the lifetime benefits of treatments. The restricted mean or median survival time (RMST) calculated using age instead of time, hypothetically enables estimation of long-term gain in event-free or overall survival from the short-term (within-trial) effects of an intervention, compared with its control. Tha aim of the study is to use trials with long-term follow-up available through extension studies to compare the long-term projections estimated using RMST from within-trial follow-up data with the actual long-term outcomes in the extension studies.

Methods and results

We estimated the media

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC9715817 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature