The difference between cystatin C- and creatinine-based assessment of kidney function in acute heart failure.

ABSTRACT:

Aims

Acute heart failure (HF) is associated with muscle mass loss, potentially leading to overestimation of kidney function using serum creatinine-based estimated glomerular filtration rate (eGFR_sCr ). Cystatin C-based eGFR (eGFR_CysC ) is less muscle mass dependent. Changes in the difference between eGFR_CysC and eGFR_sCr may reflect muscle mass loss. We investigated the difference between eGFR_CysC and eGFR_sCr and its association with clinical outcomes in acute HF patients.

Methods and results

A post hoc analysis was performed in 841 patients enrolled in three trials: Diuretic Optimization Strategy Evaluation (DOSE), Renal Optimization Strategies Evaluation (ROSE), and Cardiorenal Rescue Study in Acute Decompens

SUBMITTER: Pinsino A 

PROVIDER: S-EPMC9715858 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature