Peak O₂ -pulse predicts exercise training-induced changes in peak VO₂ in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Exercise training (ET) has been consistently shown to increase peak oxygen consumption (V̇O₂ ) in patients with heart failure with preserved ejection fraction (HFpEF); however, inter-individual responses vary significantly. Because it is unlikely that ET-induced improvements in peak V̇O₂ are significantly mediated by an increase in peak heart rate (HR), we aimed to investigate whether baseline peak O₂ -pulse (V̇O₂  × HR^-1 , reflecting the product of stroke volume and arteriovenous oxygen difference), not baseline peak V̇O₂ , is inversely associated with the change in peak V̇O₂ (adjusted by body weight) following ET versus guideline control (CON) in patients with HFpEF.

Methods and results

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SUBMITTER: Mueller S 

PROVIDER: S-EPMC9715878 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature