Right ventricular and atrial strain in patients with advanced melanoma undergoing immune checkpoint inhibitor therapy.

ABSTRACT:

Aims

While immune checkpoint inhibitor (ICI) therapy significantly improves survival rates in advanced melanoma, ICI can evoke severe immune-related cardiovascular adverse events. Right ventricular (RV) dysfunction negatively impacts the outcomes in cardiovascular diseases and may be an early sign for overall cardiotoxicity. We aimed to assess RV function in melanoma patients undergoing ICI therapy using conventional echocardiographic and strain imaging techniques.

Methods and results

We retrospectively examined 30 patients (40% women, age 59 ± 13 years) with advanced melanoma (stage III/IV) before and 4 weeks after the start of ICI therapy (follow-up at 39 ± 15 days); n = 15 of the patients received nivolumab, and n = 15 received the combination therapy nivolumab/ipilimumab

SUBMITTER: Pohl J 

PROVIDER: S-EPMC9715888 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature