Dataset Information

Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress.

ABSTRACT:

Background

Peripheral neuropathy is a dose-limiting adverse effect of vincristine (VCR) in cancer chemotherapies. Dapsone is commonly used for the prevention of opportunistic infections following cancer therapies. Therefore, a high rate of VCR and dapsone co-administration has occurred in leukemias. Recently neuroprotective effects of dapsone have been reported in various diseases.

Objectives

Regarding the physiopathology of VCR-induced peripheral neuropathy (VIPN) and dapsone neuroprotection, this study evaluated the effect of dapsone on VIPN.

Methods

VIPN was induced by VCR injection (0.5 mg/kg IP, every other day, 1 week) in male Wistar rats. In the treatment group, dapsone(12.5 mg/kg IP, 1 week) was injected 30 min before VCR. Hot plate, Von Frey, motor neuron conduction velocity (MNCV), and histopathological tests were applied. The levels of TNF-α and NF-kB in the sciatic nerve and caspase-3 activity in dorsal root ganglion were measured by the ELISA method. The levels of malondialdehyde (MDA) and Glutathione (GSH) in the sciatic nerve were measured by spectrophotometry and colorimetric assays.

Results

VIPN was observed as araised thermal and mechanical threshold, reduced MNCV, and sciatic nerve demyelination. However, dapsone reduced the mechanical and thermal threshold and improved the MNCV. Also, dapsone reduced TNF-α, NF-kB, MDA, and Caspase-3 activity, and increased the GSH level in the sciatic nerve. Moreover, dapsone prevented VCR-induced demyelination in the sciatic nerve.

Conclusion

This research demonstrated that dapsone could be used as a protective drug against VIPN. It improves the impaired thermal and mechanical sensations by reducing inflammatory, oxidant, and apoptosis factors and preventing demyelination in the sciatic nerve.

SUBMITTER: Shayesteh S

PROVIDER: S-EPMC9715892 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress.

Shayesteh Sevda S Khalilzadeh Mina M Takzaree Nasrin N Dehpour Ahmad Reza AR

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20220915 2

<h4>Background</h4>Peripheral neuropathy is a dose-limiting adverse effect of vincristine (VCR) in cancer chemotherapies. Dapsone is commonly used for the prevention of opportunistic infections following cancer therapies. Therefore, a high rate of VCR and dapsone co-administration has occurred in leukemias. Recently neuroprotective effects of dapsone have been reported in various diseases.<h4>Objectives</h4>Regarding the physiopathology of VCR-induced peripheral neuropathy (VIPN) and dapsone neu ...[more]

PMID: 36104653

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Dataset Information

Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress.

Background

Objectives

Methods

Results

Conclusion

Publications

Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress.

Similar Datasets

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