Dapsone improves the vincristine-induced neuropathic nociception by modulating neuroinflammation and oxidative stress.

ABSTRACT:

Background

Peripheral neuropathy is a dose-limiting adverse effect of vincristine (VCR) in cancer chemotherapies. Dapsone is commonly used for the prevention of opportunistic infections following cancer therapies. Therefore, a high rate of VCR and dapsone co-administration has occurred in leukemias. Recently neuroprotective effects of dapsone have been reported in various diseases.

Objectives

Regarding the physiopathology of VCR-induced peripheral neuropathy (VIPN) and dapsone neuroprotection, this study evaluated the effect of dapsone on VIPN.

Methods

VIPN was induced by VCR injection (0.5 mg/kg IP, every other day, 1 week) in male Wistar rats. In the treatment group, dapsone(12.5 mg/kg IP, 1 week) was injected 30 min before VCR. Hot plate, Von Frey, motor neuron con

SUBMITTER: Shayesteh S 

PROVIDER: S-EPMC9715892 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature