The glucotoxicity protecting effect of honokiol in human hepatocytes via directly activating AMPK.

ABSTRACT:

Introduction

Sustained hyperglycemia causes glucotoxicity, which has been regarded as a contributor to hepatocyte damage in type 2 diabetes (T2D) and its metabolic comorbidities. Honokiol is a natural biphenolic component derived from the dietary supplement Magnolia officinalis extract. This study aimed to investigate the effects of honokiol on glucose metabolism disorders and oxidative stress in hepatocytes and the underlying mechanisms.

Methods

HepG2 cells were treated with glucosamines (18 mM) to induce glucotoxicity as a diabetic complication model in vitro.

Results and discussion

Honokiol significantly increased glucose consumption, elevated 2-NBDG uptake, and promoted GLUT2 translocation to the plasma membrane in glucosamine-treated HepG2 cells, in

SUBMITTER: Liu H 

PROVIDER: S-EPMC9716082 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature