Immunoinformatic-guided designing of multi-epitope vaccine construct against Brucella Suis 1300.

ABSTRACT: Brucella suis mediates the transmission of brucellosis in humans and animals and a significant facultative zoonotic pathogen found in livestock. It has the capacity to survive and multiply in a phagocytic environment and to acquire resistance under hostile conditions thus becoming a threat globally. Antibiotic resistance is posing a substantial public health threat, hence there is an unmet and urgent clinical need for immune-based non-antibiotic methods to treat brucellosis. Hence, we aimed to explore the whole proteome of Brucella suis to predict antigenic proteins as a vaccine target and designed a novel chimeric vaccine (multi-epitope vaccine) through subtractive genomics-based reverse vaccinology approaches. The applied subsequent hierarchical shortlisting resulted in the identificatio

SUBMITTER: Jalal K 

PROVIDER: S-EPMC9716126 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature