Dataset Information
Captivity and geography influence the antibiotic resistome of non-human primates.
Ontology highlight
ABSTRACT: Introduction
Antibiotic resistance poses a serious threat for animals and humans health worldwide. Yet a comprehensive exploration of the influence of captivity and geography on non-human primate (NPH) gut antibiotic resistance remains incomplete.Methods
In this study, 131 metagenomic sequencing datasets of five species of NHPs included different regions and lifestyles were selected to perform the antibiotic resistance analysis.Results
Nineteen related resistance antibiotics and 325 antibiotic resistance genes (ARGs) were obtained. A significantly higher abundance and diversity index of ARGs in the captive NHPs than in the wild was found but not for all of the samples. The biomarker-tracking of ARGs analysis identified key ARGs related to aminoglycoside resistance genes and tetracycline resistance genes.Discussion
These results suggest that captivity and geography changes associated with human activities can lead to marked changes in the ecology of the NHP gut flora ARGs.
SUBMITTER: Huang H
PROVIDER: S-EPMC9716204 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Captivity and geography influence the antibiotic resistome of non-human primates.
Frontiers in veterinary science 20221118
<h4>Introduction</h4>Antibiotic resistance poses a serious threat for animals and humans health worldwide. Yet a comprehensive exploration of the influence of captivity and geography on non-human primate (NPH) gut antibiotic resistance remains incomplete.<h4>Methods</h4>In this study, 131 metagenomic sequencing datasets of five species of NHPs included different regions and lifestyles were selected to perform the antibiotic resistance analysis.<h4>Results</h4>Nineteen related resistance antibiot ...[more]