CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity.

ABSTRACT: T cell-mediated immunotherapy represents a promising strategy for cancer treatment; however, it has achieved satisfactory clinical responses in only a limited population. Thus, a broader view of the T-cell immune response is required. The Ras/MAPK pathway operates in many important signaling cascades and regulates multiple cellular activities, including T-cell development, proliferation, and function. Herein, we found that the typical membrane-bound complement regulatory protein CD59 is located intracellularly in T cells and that the intracellular form is increased in the T cells of patients with cancer. When intracellular CD59 is abundant, it facilitates Ras transport to the inner plasma membrane via direct interaction; in contrast, when CD59 is insufficient or deficient, Ras is arrested

SUBMITTER: Li L 

PROVIDER: S-EPMC9716252 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature