Antarctic Sphingomonas sp. So64.6b showed evolutive divergence within its genus, including new biosynthetic gene clusters.

ABSTRACT:

Introduction

The antibiotic crisis is a major human health problem. Bioprospecting screenings suggest that proteobacteria and other extremophile microorganisms have biosynthetic potential for the production novel antimicrobial compounds. An Antarctic Sphingomonas strain (So64.6b) previously showed interesting antibiotic activity and elicitation response, then a relationship between environmental adaptations and its biosynthetic potential was hypothesized. We aimed to determine the genomic characteristics in So64.6b strain related to evolutive traits for the adaptation to the Antarctic environment that could lead to its diversity of potentially novel antibiotic metabolites.

Methods

The complete genome sequence of the Antarctic strain was obtained and mined for Biosynthetic Ge

SUBMITTER: Nunez-Montero K 

PROVIDER: S-EPMC9716278 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature