Integrated multi-omics reveals novel microbe-host lipid metabolism and immune interactions in the donkey hindgut.

ABSTRACT: Evidence has shown that gut microbiota play a key role in host metabolism and health; however, little is known about the microbial community in the donkey hindgut as well as the interactions that occur between gut microbes and the host. This study aimed to explore the gut microbiome differences by analyzing the microbial community and differentially expressed genes (DEGs) related to lipid metabolism and the immune system along the donkey hindgut. The hindgut tissues (cecum, ventral colon, and dorsal colon) were separated, and the contents of each section were collected from six male donkeys for multi-omics analysis. There were significant differences in terms of dominant bacteria among the three sections, especially between the cecum and dorsal colon sites. For instance, species belonging

SUBMITTER: Li Y 

PROVIDER: S-EPMC9716284 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature