Patient-derived xenograft models for gastrointestinal tumors: A single-center retrospective study.

ABSTRACT:

Background

Patient-derived xenograft (PDX) models have shown a great efficiency in preclinical and translational applications. Gastrointestinal (GI) tumors have a strong heterogeneity, and the engraftment rate of PDX models remarkably vary. However, the clinicopathological and molecular characteristics affecting the engraftment rate still remain elusive.

Methods

A total of 312 fresh tumor tissue samples from patients with GI cancer were implanted into immunodeficient mice. The median follow-up time of patients was 37 months. Patients' characteristics were compared in terms of PDX growth and overall survival. PDX models of 3-6 generations were used for drug evaluation.

Results

In total, 171 (54.8%, 171/312) PDX models were established, including 85 PDX models of colore

SUBMITTER: Yu X 

PROVIDER: S-EPMC9716308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature