Monocyte adaptations in patients with obesity during a 1.5 year lifestyle intervention.

ABSTRACT:

Background

Obesity is associated with chronic, low-grade inflammation, which is reflected in altered peripheral blood monocyte characteristics. The aim of this study was to analyze the monocyte subset composition (classical (CM), intermediate (IM) and non-classical monocytes (NCM)), and their inflammatory marker profile (CD14, CD16, CD36, CD45, CD64, CD300e, HLA-DR) in individuals with obesity during a 1.5 year combined lifestyle intervention (CLI), comprising healthy nutrition, increased exercise and behavioral changes.

Methods

We analyzed monocyte subset counts and immunophenotypes in 73 individuals with obesity, and associated these to baseline body mass index (BMI) and waist circumference (WC). The measurements were repeated after 10 weeks and at the end of the intervent

SUBMITTER: van der Valk ES 

PROVIDER: S-EPMC9716348 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature