SARS-CoV-2 antibody responses post-vaccination in UK healthcare workers with pre-existing medical conditions: a cohort study.

ABSTRACT:

Objectives

To examine antibody responses after the second vaccination in healthcare workers (HCWs) with underlying health conditions.

Design

Cohort study.

Setting

Oxford University Hospitals in the United Kingdom.

Participants

Healthcare workers who had SARS-CoV-2 serological data available and received two SARS-CoV- 2 vaccinations.

Primary outcome

Peak SARS-CoV-2 anti-spike IgG responses after the second vaccination and associations with underlying health conditions and the estimated risk of severe COVID-19 using an occupational health risk assessment tool.

Methods

We used univariable and multivariable linear regression models to investigate associations between antibody levels and demographics (age, sex, ethnicity), healthcare role, body mass in

SUBMITTER: Ward V 

PROVIDER: S-EPMC9716410 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature