Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials.

ABSTRACT: Super-selective multivalent ligand-receptor interactions display a signature step-like onset in binding when meeting a characteristic density of target receptors. Materials engineered for super-selective binding generally display a high number of flexible ligands to enhance the systems' avidity. In many biological processes, however, ligands are present in moderate copy numbers and arranged in spatio-temporal patterns. In this low-valency regime, the rigidity of the ligand-presenting architecture plays a critical role in the selectivity of the multivalent complex through decrease of the entropic penalty of binding. Exploiting the precision in spatial design inherent to the DNA nanotechnology, we engineered a library of rigid architectures to explore how valency, affinity, and nano-spacing

SUBMITTER: Bila H 

PROVIDER: S-EPMC9716526 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature