M⁶A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) is an abundant post-transcriptional RNA modification that affects various biological processes. The fat mass and obesity-associated (FTO) protein, a demethylase encoded by the FTO gene, has been found to regulate adipocyte development in an m⁶A-dependent manner in multiple species. However, the effects of the m⁶A methylation and FTO demethylation functions on chicken adipogenesis remain unclear. This study aims to explore the association between m⁶A modification and chicken adipogenesis and the underlying mechanism by which FTO affects chicken preadipocyte development.

Results

The association between m⁶A modification and chicken lipogenesis was assessed by treating chicken preadipocyte

SUBMITTER: Li K 

PROVIDER: S-EPMC9716549 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature