Effect of add-on sacubitril/valsartan on the left ventricular hypertrophy of a patient with hypertension.

ABSTRACT: The combination of sacubitril and valsartan has recently become eligible for reimbursement in Japan for the treatment of hypertension. However, the real-world clinical efficacy of sacubitril/valsartan in patients with hypertension who are taking multiple anti-hypertensive medications remains to be characterized. We treated a man in his late 40s who had undergone a percutaneous coronary intervention and had hypertension that was refractory to multiple anti-hypertensive medications. We initiated sacubitril/valsartan 200 mg/day as an add-on therapy, and 3 months later, his blood pressure had decreased from 154/78 mmHg to 134/70 mmHg, in the absence of any drug-related adverse events. Furthermore, his left ventricular mass index had improved from 135 g/m² to 112 g/m². Thus, sacubitril/valsartan might ameliorate hypertrophy in patients with hypertension.

SUBMITTER: Imamura T 

PROVIDER: S-EPMC9716615 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature