TF and TCF4 gene polymorphisms are linked to autism spectrum disorder: a case-control study.

ABSTRACT:

Objective

Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case-control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively.

Methods

Ninety-six children with ASD and 118 healthy children were recruited and polymerase chain reaction-restriction fragment length polymorphism technique was applied for genotyping.

Results

The frequencies of the mutant allele G were 48% and 44% for the rs1867503 and rs9951150 polymorphisms, respectively. In our analysis, both TF and TCF4 polymorphisms were associated with an increased risk of developing ASD. AG heterozygotes (OR 

SUBMITTER: Azmerin M 

PROVIDER: S-EPMC9716618 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature