Injectable PTHF-based thermogelling polyurethane implants for long-term intraocular application.

ABSTRACT:

Background

Hydrogels show great potential to be used for intraocular applications due to their high-water content and similarity to the native vitreous. Injectable thermosensitive hydrogels through a small-bore needle can be used as a delivery system for drugs or a tamponading substitute to treat posterior eye diseases with clear clinical potential. However, none of the currently available thermosensitive hydrogels can provide intraocular support for up to 3 months or more.

Method

In this study, an injectable polytetrahydrofuran (PTHF)-based thermosensitive hydrogel was synthesized by polyurethane reaction. We examined the injectability, rheological properties, microstructure, cytotoxicity, and in vivo compatibility and stability of the hydrogels in rabbit eyes.

Results</

SUBMITTER: Zhang K 

PROVIDER: S-EPMC9716749 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature