PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders.

ABSTRACT:

Background

Neurocognitive disorders and psychosocial difficulties are common in patients with Turner syndrome and multiple neurodegenerative diseases, yet there is no effective cure. Human primordial germ cells (hPGCs) are pluripotent germline stem cells in early embryo, which pass genetic information from one generation to the next, whereas all somatic cells will die along with the end of life. However, it is not known whether patient hPGCs with Turner syndrome contain information of neurocognitive and psychosocial illness.

Results

In this report, we used a high-density of culture system of embryoids derived from iPSCs of a patient with Turner syndrome to ask how pathogenetic pathways are associated with onset of neurocognitive and psychosocial disorders. The hPGC-Like Cell

SUBMITTER: Shang D 

PROVIDER: S-EPMC9716775 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature