Sex-specific correlates of valvular and arterial calcification burden in patients with moderate aortic stenosis.

ABSTRACT:

Introduction

There are significant sex differences in the prevalence and severity of cardiac calcifying processes. Women harbour more severe mitral annular calcification (MAC), while men exhibit worse aortic valve (AVC) and coronary artery (CAC) calcification. To better understand these differences, we investigated the correlates of cardiac calcification according to sex.

Methods

We conducted a cross-sectional study of 406 patients with ≥mild aortic stenosis (AS) defined by an aortic valve area ≤1.5 cm², a peak aortic jet velocity >2.0 m/s, or a mean transvalvular gradient >15 mm Hg. Doppler-echocardiography and non-contrast multidetector CT were performed concomitantly to assess AS and cardiac calcifications.

Results

Mean age was 71±11 years and 33% were w

SUBMITTER: Deslandes M 

PROVIDER: S-EPMC9716845 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature