Mitochondrial toxicants in Xian-Ling-Gu-Bao induce liver injury by regulating the PI3K/mTOR signaling pathway: an in vitro study.

ABSTRACT:

Background

Drug-induced mitochondrial toxicity is thought to be a common mechanism of drug hepatotoxicity. Xian-Ling-Gu-Bao (XLGB) oral preparation is a commonly used drug for osteoporosis in China. Classical safety evaluation studies have shown that the entire preparation and six Chinese herbal medicines have high safety, but the incidence of drug-induced liver damage due to XLGB remains high, the mechanism and toxic substances causing liver injury are still unclear. The purpose of this study is to identify compounds with potential mitochondrial liabilities in XLGB, and to clarify their underlying mechanisms and related pathways.

Methods

The mitochondrial function analysis was performed using an extracellular flux assay, which simultaneously monitored both oxygen consumptio

SUBMITTER: Piao S 

PROVIDER: S-EPMC9716976 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature