Calcium ionophore improves embryonic development and pregnancy outcomes in patients with previous developmental problems in ICSI cycles.

ABSTRACT:

Background

Calcium (Ca²⁺) ionophores are now mainly considered as efficient treatments for fertilization failure. Recently, its application for rescuing poor embryo development was proposed but still non-routine. This study aimed to explore whether Ca²⁺ ionophore improves embryo development and pregnancy outcomes in patients with poor embryo development in previous intracytoplasmic sperm injection (ICSI) cycles.

Methods

This study included 97 patients undergoing assisted oocyte activation (AOA) with Ca²⁺ ionophore (calcimycin, A23187) treatment. Preimplantation embryonic development and clinical outcomes were compared between ICSI-AOA cycles (AOA group) and previous ICSI cycles of the same patients in which poor embryo developmental potential

SUBMITTER: Chen X 

PROVIDER: S-EPMC9717248 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature